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Beilstein J. Org. Chem. 2014, 10, 155–162, doi:10.3762/bjoc.10.13
Graphical Abstract
Figure 1: Structures of dimebon and SS peptides.
Scheme 1: Synthesis of starting N-substituted tetrahydro-γ-carbolines 3a–d.
Scheme 2: Synthesis of peptides 5 through the Ugi reaction.
Scheme 3: Synthesis of N-substituted tetrahydro-γ-carbolines containing protected peptide residues.
Scheme 4: Synthesis of dihydrochloride salts 7a–g.